Dr. Minghui Li

Dr. Minghui Li obtained his Ph.D. from the Chinese Academy of Sciences in Dr. Dongcai Liang’s lab and did the postdoctoral research at Columbia University with Dr. Jian Yang. Minghui developed MegaR & MegAb platform technology, which is especially powerful in : - production of difficult-to-express GPCRs - cryo-EM structure determination of small-size GPCRs in complexes with antagonists - GPCR antibody drug discovery Minghui has solved cryo-EM structures of: - first eukaryotic cyclic nucleotide-gated channel - human TRPML3 channel in three distinct states - Plasmodium falciparum multi-drug resistant (MDR) 1 transporter in different conformations